Diminished Polymorphonuclear Leukocyte Adherence
نویسندگان
چکیده
منابع مشابه
Polymorphonuclear leukocyte adherence to nylon: effect of oral corticosteroids.
The effect of orally administered glucocorticoids on polymorphonuclear leukocyte adherence was studied by using the nylon fiber adherence assay. Inhibition of adherence 4 h after administration of the agent was confirmed, and in addition, augmentation of adherence was noted 24 h after ingestion of prednisone. Crossover studies revealed inhibition and augmentation to be cell associated as well a...
متن کاملPolymorphonuclear Leukocyte Chemotactic Activity
serum and guinea pig serum treated with preformed immune complexes. Normal rabbit sera, guinea pig sera, or rabbit sera deficient in C6 were treated with homologous antibovine serum-albumin-bovine serum-albumin complexes. Sera so treated contained one major PMN chemotactic factor which was heat-stable (56 C for 30 min), had a molecular weight of approximately 15,000, and did not require the pre...
متن کاملPolymorphonuclear Leukocyte and Monocyte
its elaboration. The chemotactic activity of crudeculture supernate was heat stable (56°C for 30 min), trypsinand pronase-sensitive, and neuraminidase resistant. Characterization of the chemotactic activity by gel filtration (Sephadex G-75) showed two active fractions, one with mol wt >100,000 and the other <10,000. In studies designed to relate these chemotactic factors to collagen, we have co...
متن کاملPolymorphonuclear Leukocyte Lysosomes
cytes. Both androstenedione and progesterone, 10 -10' M, caused leakage of acid hydrolase markers from these organelles, thus resembling their effects on liver lysosomes. But none of the anti-inflammatory steroids tested protected organelle membranes from either detergent lysis (Triton X-100) or heat incubation (37GC, 90 min). Hydrocortisone (HC), HC sodium succinate, HC acetate, HC hemisuccina...
متن کاملDefective Polymorphonuclear Leukocyte Formyl Peptide
Juvenile periodontitis (JP) is a disease characterized by severe gingival infections. PMN from some JP patients exhibit abnormal chemotactic responsiveness when challenged with the synthetic formyl peptide, FMLP. While investigating PMN function in JP, we found a patient in whom abnormal PMN chemotactic responses to FMLP were associated with a defective population of PMN formyl peptide receptor...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1980
ISSN: 0021-9738
DOI: 10.1172/jci109853